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Istradefylline 40 mg/day elevated peak degrees and AUC of CYP3A4 substrates in scientific trials. This influence was not observed with istradefylline 20 mg/working day. Consider dose reduction of sensitive CYP3A4 substrates.Hou et al (2005) researched the autonomic consequences of modafinil in individuals. They observed that modafinil has an effect